Studies indicate that ingested oral cyanocobalamin tablets are ineffective in the treatment of allergic disease, perhaps because once ingested, home they are directly metabolized in the liver. When B12 is delivered via injection or lozenge it passes throughout remedy the bloodstream before arriving for at the liver. sinus It is during this first pass in its native home and remedy form that it is believed to exert its therapeutic effect. CLINICAL for and sinus RESEARCH: "The World home Health Organization (WHO) recognizes allergic rhinitis (hay fever), sinusitis, asthma,...conjunctivitis, urticaria, remedy eczema, dermatitis (contact and atopic)...allergic and migraine headache...as diseases in which IgE-mediated allergy may be involved."1 for In 1988, asthma and allergic rhinitis subjects were treated with B12. sinus Total IgE, specific IgE and pulmonary home lung functions were taken at days 45, 150 and 180 from remedy baseline. Eight of the 9 for and sinus subjects home had reduced remedy and for and sinus and home IgE. 2 In 1989 open label studies at two sites remedy in Riverside County, CA in 1989. Sixteen of the 17 subjects had lowered IgE levels from Day 0 to Day 30.3

With no further treatment, the 1996 ten-month follow-up data (n=92) from a high pollen for period in Oregon, sinus Washington home and Idaho together showed a greater reduction in the active group (n=43) remedy than the placebo group (n=49) on the primary endpoint, defined as a combination of symptom and rescue medication scores.8 Patients gave blood serum samples prior to the treatment for in sinus 1995 and one year later in home 1996. They remedy were immunoassayed for specific IgE antibodies using a chemi-luminescent technique. for Statistician Bradley Rosebrook ran sinus T-Tests comparing average baseline IgE levels to one-year. For the seasonal allergens reported, home the active group (n=27) had on average a greater reduction in remedy IgE than for and sinus the placebo group (n=34) for 13 out of 16 allergens.8